Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. More hippocampal neurons in adult mice living in an enriched environment. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Delayed coupling to feedback inhibition during a critical period for the integration of adult-born granule cells.
Optical controlling reveals time-dependent roles for adult-born dentate granule cells. Distinct contribution of adult-born hippocampal granule cells to context encoding. Unique processing during a period of high excitation/inhibition balance in adult-born neurons. A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain. Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus. Adult neurogenesis in the mammalian hippocampus: why the dentate gyrus? Learn. Functional neurogenesis in the adult hippocampus. Adult neurogenesis in the mammalian brain: significant answers and significant questions. Our study identifies a key hypothalamic circuit that couples novelty signals to the production and maturation of ABNs, and highlights the activity-dependent contribution of circuit-modified ABNs in behavioral regulation. Moreover, SuM is required for ABN activity-dependent behavioral modulation under a novel environment. Furthermore, we show that SuM neurons are highly responsive to environmental novelty (EN) and are required for EN-induced enhancement of neurogenesis. Functionally, selective manipulation of the activity of these SuM-promoted ABNs modulates memory retrieval and anxiety-like behaviors.
Here we report that chronic patterned optogenetic stimulation of supramammillary nucleus (SuM) neurons in the mouse hypothalamus robustly promotes neurogenesis at multiple stages, leading to increased production of neural stem cells and behaviorally relevant adult-born neurons (ABNs) with enhanced maturity. However, it remains unknown whether manipulation of neural circuit activity can achieve sufficient neurogenic effects to modulate behavior. Adult hippocampal neurogenesis plays a critical role in memory and emotion processing, and this process is dynamically regulated by neural circuit activity.
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